WebAug 1, 2024 · Abstract. In this issue of Blood, Li et al show that erythropoietin receptor (Epor) expression marks the central macrophage of the erythroblastic island (EBI). Treatment with Epo increases the number of EBIs as well as the number of erythroblasts surrounding the central macrophage. WebAug 1, 2024 · Erythroblastic island (EBI), composed of a central macrophage surrounded by developing erythroid cells, is a structure found in hematopoietic tissues such as fetal liver and bone marrow. It is the first described hematopoietic …
Identification and Functional Analysis of EPOR Tumor
WebAug 1, 2024 · We show that in bone marrow (BM) and fetal liver, a subset of macrophages express Epor-eGFP. Imaging flow cytometry analyses revealed that >90% of native EBIs … WebAug 1, 2024 · RNA-seq analyses of BM F4/80 + Epor-eGFP + and F4/80 + Epor-eGFP-macrophages. (A) Principal component analysis. (B) Heatmap of the differentially … thule outway parts
Frontiers Erythroblastic Island Macrophages Shape Normal ...
WebSpecifically, it has been reported that EPOR can be expressed by macrophages in bone marrow (BM), spleen (SP), fetal liver (FL), liver, and peritoneum, which are respon- sivetoEPO[24–27].CD163isthemainmarkeronTAMsand isassociatedwithapoorprognosisinpatientswithcancer[28, 29]. WebNov 18, 2024 · Notably, accumulating evidence suggests that EpoR is expressed well beyond erythroid cells. However, the expression of EpoR in non-erythroid cells has been … WebMay 17, 2024 · Using pEKLF/GFP mice, the Bieker group has shown that ~36% of mouse FL F4/80 + macrophages express EKLF (Klf1) and that Klf1 deficiency significantly impaired the function of central macrophages. 64 In this study, using Epor-eGFPcre mice we showed that ~31% of mouse FL F4/80 + macrophages expressed Epor. thule outway platform 2 kompatibilität