2024 Hepatic asialoglycoprotein receptor

Hepatic asialoglycoprotein receptor

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Web2 aug. 2012 · The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Web5 mei 2016 · ASGR1 has long been recognized as a hepatic surface marker (Ashwell and Morell, 1974; Schwartz et al., ... Detection of circulating tumor cells in hepatocellular …

The Asialoglycoprotein Receptor Mediates Hepatic Binding and …

Web1 jul. 1995 · Transport of macromolecules into the cell by receptor-mediated endocytosis follows a complex series of intracellular transfers, passing through distinct environments. … Web1 jan. 2001 · The hepatic asialoglycoprotein receptor was the first of the mammalian lectins to be recognized and has been the subject of intense investigation for three decades. Yet, the precise biological role of this major hepatic endocytic receptor has remained elusive. We describe here the characterization of the mouse gene for the major subunit … triage category nhs

Endocytosis and function of the hepatic asialoglycoprotein receptor

Web1 nov. 1994 · The Asialoglycoprotein Receptor Mediates Hepatic Binding and Uptake of Natural Hepatitis B Virus Particles Derived From Viraemic Carriers Microbiology Society Volume 75, Issue 11 Research Article Free The Asialoglycoprotein Receptor Mediates Hepatic Binding and Uptake of Natural Hepatitis B Virus Particles Derived From … Web5 mei 2016 · ASGR1 has long been recognized as a hepatic surface marker (Ashwell and Morell, 1974; Schwartz et al., ... Detection of circulating tumor cells in hepatocellular carcinoma using antibodies against asialoglycoprotein receptor, carbamoyl phosphate synthetase 1 and pan-cytokeratin. PLoS ONE 9, e96185 10.1371/journal.pone.0096185 ... WebThe asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the … triage centers for short

Asialoglycoprotein receptor 1 - Wikipedia

ASGR1 and ASGR2, the Genes that Encode the Asialoglycoprotein …

WebAsialo- (i.e., galactose-terminal) glycoproteins are specifically and avidly recognized by a mammalian hepatic parenchymal cell receptor. This receptor, itself a glycoprotein, … WebAsialoglycoprotein receptors (ASGPR) have also been termed mammalian hepatic lectin, galactose-specific receptors, or “galaptins” and are completely characterized as … tennis heads mousebreakerWeb25 dec. 2001 · The role of the asialoglycoprotein receptor in clearance was studied by preinjection (at 1 min before injection of the radiolabel) of 50 mg·kg −1 body weight of asialo-fetuin (a blocker of the asialoglycoprotein receptor). Injection of α3-galactosylated α 1 -AGP was done in duplicate, that of asialo-α 1 -AGP in triplicate. triage cencer

"The asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), … Meer weergeven The asialoglycoprotein receptor was first characterized in 1968 by Morell et al. and was the first mammalian lectin identified. The researchers transferred radioactively-labeled ceruloplasmin that had undergone a reaction … Meer weergeven • Asialoglycoprotein+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven Asialoglycoprotein receptors function to catabolize galactosyl and N-acetylgalactosaminyl-containing substrates. More specifically, in most mammals, … Meer weergeven The human asialoglycoprotein receptors composed of two units, H1 and H2. Each of these units have their N-terminus within the cytoplasm of a liver cell, and a carbohydrate recognition domain (CRD) on the extracellular side. The CRD functions to … Meer weergeven " - Hepatic asialoglycoprotein receptor

Hepatic asialoglycoprotein receptor

Asialoglycoprotein receptor (ASGPR): a peculiar target of liver

WebAs a putative mechanism of hepatitis B virus (HBV) uptake into hepatocytes the interaction between HBV and the hepatic, human-derived asialoglycoprotein receptor … Web18 okt. 2024 · Human genetic studies combined with biotechnological advances have guided and accelerated the development of PCSK9-targeting therapies. In this Clinical Outlook, we highlight present and future ...

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Web11 okt. 2024 · The asialoglycoprotein receptor (ASGPR), a high-capacity C-type lectin receptor, is frequently expressed on hepatocytes (500,000 ASGPR/hepatocyte) and minimally expressed on other tissues. The physiological function of this receptor is the specific binding and internalization of galactose (Gal), and because of this, it is frequently … WebMost notable of these is the asialoglycoprotein receptor (ASGPR1), a liver-specific protein that is highly produced in well-differentiated hepatocytes. Its utility as a definitive marker of hepatocyte identity is well established, and it has been used to isolate stem cell-derived hepatocytes. 51 As shown in Figure 4 , ASGPR1 is expressed on the cell surface by …

Web10 apr. 2015 · The asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally on extra-hepatic cells. This makes it specifically attractive for receptor-mediated drug delivery with minimum concerns of toxicity. ASGPR facilitates internalization by clathrin-mediated endocytosis and exhibits high affinity for … WebAbstract. The asialoglycoprotein receptor (ASGPR) is a high-capacity C-type lectin receptor mainly expressed on mammalian hepatic cells. The physiological function of …

Web29 mrt. 2024 · In this work, we report the evaluation of lactosylated graphene oxide (GO-AL) as a potential drug carrier targeted at an asialoglycoprotein receptor (ASGPR) from hepatic cancer cells. Structural-modification, safety evaluation, and functional analysis of GO-AL were performed. Web20 apr. 2001 · The asialoglycoprotein receptor (ASGPR) 1 was originally identified by Ashwell and Morell as a hepatic receptor that mediates the rapid clearance of serum glycoproteins containing terminal galactose residues …

Web21 mrt. 2024 · The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The …

Web22 nov. 2011 · A well-established target for specific drug delivery to hepatocytes is the hepatic C-type lectin asialoglycoprotein receptor (ASGPR). ASGPR is expressed at high levels on hepatocytes (approximately 500,000 copies/cell) and plays an important role in the clearance of desialylated glycoproteins from serum via receptor mediated endocytosis … triage ccssWebIntroduction. SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and its damaging effects on both health and economics worldwide. Transmission and pathology of the virus appears to be mediated through the respiratory system via interaction of the viral spike protein with the ACE-2 receptor 1–3 differentially presented on various cells within … tennis head sizeWeb17 jul. 2024 · Desialylated platelets are reportedly cleared by hepatocytes via the hepatic asialoglycoprotein receptor (ASGPR) (also called the Ashwell–Morell receptor (AMR); … triage centers during warWebThe hepatic asialoglycoprotein receptor (ASGP-R) is an organ-specific hetero-oligomeric C-type lectin, consisting of a major 48 kDa (ASGP-R1) and a minor 40 kDa subunit (ASGP-R2). This transmembrane protein is expressed primarily at the sinusoidal surface of the liver hepatocyte cells, which recognizes terminal β-galactosyl and β- N -acetyl-galactosaminyl … tennis head to head wtaWebEndocytosis and function of the hepatic asialoglycoprotein receptor Subcell Biochem. 1993;19:125-61. doi: 10.1007/978-1-4615-3026-8_5. Author P H Weigel 1 Affiliation 1 … triage cell phone forensicsWeb20 jan. 2000 · The human asialoglycoprotein receptor (ASGPR), also called hepatic lectin, is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis. tennis heads unblockedWebInhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor . 肝癌是常见的恶性肿瘤之一，是我国位居第二的癌症“杀手”，虽然早期亚临床肝癌手术切除治疗效果较好，但是多数患者就诊时肿瘤已进展至晚期，有效治疗方法不多。 tennis health