Honokiol and breast cancer
WebTriple-negative breast cancer (TNBC) is a subtype of breast cancer in which estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER 2) are not expressed. Thus, TNBC patients derive no benefit from endocrine therapy or trastuzumab. WebHonokiol bound with comparable binding energies to EGFR (−7.30 ± 0.01 kcal/mol) as the control drugs ... breast cancer resistance protein-transfected MDA-MB-231-BCRP, TP53 knockout cells (HCT116 p53(-/-)), and mutation-activated epidermal growth factor receptor-transfected U87MG.ΔEGFR cells. IC50 values below 5µg/mL of BAL were ...
Honokiol and breast cancer
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Web22 dec. 2024 · Moreover, honokiol has been shown to effectively induce apoptosis in p53-deficient cancer cells, such as MDA-MD-231 breast cancer cells, as well as lung and bladder cancer cell lines by inhibiting the activation of ras-phospholipase D [ 39, 99, 100 ]. WebBackground: Honokiol, a natural phenolic compound derived from Magnolia plants, is a promising anti-tumor compound that exerts a wide range of anti-cancer effects. Herein, …
Web1 jan. 2024 · Our previous serial studies have revealed that Honokiol can induce cancer cell apoptosis and inhibit tumorigenesis and metastasis of gastric cancer cells via endoplasmic reticulum (ER) stress-related signaling pathways and specific targeting of key calpain activation, as well as the downregulation of CRT, PPARγ, Grp94, COX-2, STAT …
Web14 apr. 2024 · Despite an increase in the incidence of breast cancer worldwide, overall prognosis has been consistently improving owing to the development of multiple targeted … WebStudy design: Honokiol has been specified as a novel alternative to treat various disorders such as liver cancer, neuroprotective, anti-spasmodic, antidepressant, …
WebRecent preclinical studies from our group and others have shown the efficacy of HNK as a potential therapy for multiple cancer types including prostate cancer, lung cancer, …
WebHonokiol (HNK) is a biphenolic compound that has been used in traditional medicine for treating various ailments, including cancers. In this study, we determined the effect of HNK on colon cancer cells in culture and in a colitis-associated cancer model. HNK treatment inhibited proliferation and colony formation while inducing apoptosis. In addition, HNK … common sense media 13 reasons whyWebI am a cancer research scientist with a strong background in molecular biology and a flair to solve problems. I am looking forward to pursuing a career in research and development where I can make ... common sense media a boy called christmasWeb30 nov. 2012 · Honokiol causes growth inhibition, tumorigenesis suppression, cell cycle arrest, apoptosis, and importantly has a synergistic effect with 5-FU in human UCC cells, which displays a therapeutic potential for treating human U CC. 3 PDF Honokiol: A Review of Its Anticancer Potential and Mechanisms C. P. Ong, W. L. Lee, Yin-Quan Tang, W. … common sense media 47 meters downWebbreast cancer cells. Our results showed that LKB1 and AMPK are integral molecules required for honokiol-mediated modulation of 4EBP1-pS6K and inhibition of migration and invasion of breast cancer cells. Materials and methods Cell culture and reagents The human breast cancer cell lines, MCF7 and MDA-MB-231, were obtained from the … dublin pride week essay contestWebCollectively, these results demonstrate that pharmacological activation of SIRT3 is a potential therapeutic approach of triple negative breast cancer (TNBC). More importantly, compound 33c may be a first-in-class specific small-molecule activator of SIRT3 that would be utilized for future cancer drug development. Supporting Information common sense media a christmas storyWeb17 aug. 2016 · Honokiol has been shown to inhibit the spread of cancer cells through the lymph system by inhibiting one of the primary pathways involved in growth … common sense media action packWeb24 jan. 2024 · Furthermore, breast (MDA-MB-231), prostate (DU145) cancer cells, leukemia (KG-1), and MLL-AF9 oncogene transformed murine splenocytes were treated with honokiol or bona fide proteasome inhibitor ... common sense media 10 things i hate about you