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Lc3-interacting region lir

Web8 apr. 2024 · Efficient localization of HyD-2xLIRs-GFP to mRFP-LC3/GABARAP-positive autophagosomes. a Schematic model depicting the development of new autophagosome sensors. LIR: LC3-interacting region, HyD: hydrophobic domain. b Confocal images showing the cellular localization of HyD-LIR(X)-GFP or HyD-2xLIR(X)-GFP together with … Web28 dec. 2024 · Binding ER-phagy receptors with LC3 occurs via an LC3-interacting region (LIR) motif [72,73]. In some cases, these receptors bind through the FIP200 protein found in the ULK complexes . ER stress activates autophagy by upregulating transcription of autophagy machinery components and modulating microtubule-associated LC3 protein.

Frontiers Disrupting the LC3 Interaction Region (LIR) Binding of ...

WebShort linear motifs, known as LC3-interacting regions (LIRs), interact with mactoautophagy/autophagy modifiers (Atg8/LC3/GABARAP proteins) via a conserved … Web22 okt. 2024 · Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Small Molecules Experimental Data & … new developments in pensacola fl https://casadepalomas.com

An atypical LIR motif within UBA5 (ubiquitin like modifier activatin…

Web2 aug. 2016 · Various studies pointed out that the interaction between receptors and Atg8-family proteins is mediated by an LC3-interacting region (LIR), also known as … Web31 mei 2024 · Thus, the LIR–LC3 interaction is essential for the formation, transport, and maturation of autophagosomes. Genetic mutations in LIR motifs may significantly alter … Web2 jun. 2024 · In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs-interacting protein and find that NEK9 and its LC3-interacting region (LIR) are required for primary cilia formation.... new developments in pittsburgh

NEK9 regulates primary cilia formation by acting as a ... - Nature

Category:Potential Mechanisms Based on the Autophagy Regulatory JIR

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Lc3-interacting region lir

Mimicked phosphorylation of Bnip3 LIR promotes mitochondrial …

Web10 jun. 2024 · LIR-mediated interaction with ATG8 proteins. The complex between LC3B and p62 [PDB entry: 2ZJD ( Ichimura et al., 2008 )] is reported as an example. LC3B mediates protein-protein interactions and recruits the autophagy receptors through the binding of a short linear motif, called LIR. Web6 feb. 2024 · LC3: microtubuleassociated protein 1A/1B-light chain 3; LIR: LC3-interacting region; BNIP3: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;NIX: NIP3-like protein X; FUNDC1: FUN14 domain-containing protein 1.

Lc3-interacting region lir

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Web23 nov. 2024 · We found that Trim5α binds all mammalian ATG8s and that, unlike the typical LC3-interacting region (LIR) that binds to mammalian ATG8s through a β … WebThe four amino acid linear LC3 interaction region (LIR) is shown in bold in its broader amino acid context. (B) Surface representation of the LIR binding site of LC3B in complex with a pS177 OPTN peptide (cyan). Region 1 (orange) and region 2 (purple) are shown.

Web2 dagen geleden · TBC1D15 localized to damaged lysosomes via its C-terminal LC3-interacting region (LIR) motif, and its N terminus served as a platform to assemble the ALR machinery. Web2 jun. 2024 · 自噬的选择性由自噬受体决定，许多自噬受体的蛋白质序列中包含LC3结合区域（LC3-interacting region, LIR），从而能够与定位在自噬体上的LC3蛋白结合，将胞质 …

WebSimilar to FUNDC1, phosphorylation near the N-terminal LC3 interaction region (LIR) of Bnip3 and Nix stabilizes their interaction with LC3 to promote mitophagy (Poole et al., 2024;Rogov et al ... Web30 jun. 2024 · Bioinformatics data-mining revealed that β-gB1 contains the canonical LIR (LC3 interacting region) motif. Functionally, we showed that the β-ginkgotide β-gB1 …

Web31 mrt. 2024 · LC3 interacting regions (LIRs), being quintessential for orchestrating diverse stages of autophagy, are a prominent example of SLiMs and mediate …

Web张慧芳，黄自能，陈蔚，孙林，刘伏友，肖力. 1中南大学湘雅二医院肾内科，长沙 410000. 自噬是消除聚集的蛋白质及受损细胞器的过程，对于缓解应激、维持细胞稳态及细胞分化等至关重要[1-2]。 internship 2021/2022Web19 dec. 2024 · Here we report that STING harbors classic LC-3 interacting regions (LIRs) and mediates autophagy through its direct interaction with LC3. We observed that poly (dA:dT), cGAMP, and HSV-1... new developments in protea glenWeb11 mei 2024 · Although the mechanism of autophagy inhibition through phosphorylation of LC3 proteins is still unclear, the possibility that phosphorylation of these sites interferes with the interaction of LC3 proteins with LIR-containing proteins is highly attractive and therefore may have serious consequences in the recruitment of AIM/LIR-dependent sensors. new developments in philadelphiaWebThe LC3-interacting region (LIR) motif as a mechanistic basis for mitophagy. a LC3B structure (PDB 1UGM) [179], analyzed using Chimera [180]. Upper panel ribbon … internship 2021 indiaWeb12 mrt. 2024 · A variety of molecules involved in the autophagic pathway engage in specific interactions with a unique sequence motif referred to as the LIR (LC3-interacting region) motif. Although identification of conserved structural features of LIR motifs in complex with LC3-family members has established a canonical LIR motif, atypical conformations of … new developments in productivity analysisWeb3 jan. 2024 · The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR) motifs that bind to the LIR docking site (LDS) of … new developments in prince william countyWeb8 mei 2024 · This collective data show that M is a binding partner of LC3. Usually, binding partners of LC3 family members typically contain an LC3-interacting region (LIR). 2 LIRs form intermolecular β... new developments in reading