As a potent repressor of beta-interferon (IFN-β), BLIMP-1 competes for interferon regulatory factors (IRF) binding sites in the IFN-β promoter due to its sequence similarity with IRF1 and IRF2. However, BLIMP-1 cools down and activates immune responses in a highly contextual manner. BLIMP-1 represses … See more PR domain zinc finger protein 1, or B lymphocyte-induced maturation protein-1 (BLIMP-1), is a protein in humans encoded by the gene PRDM1 located on chromosome 6q21. BLIMP-1 is considered a 'master regulator' of See more BLIMP-1 is an important regulator of plasma cell differentiation. During B cell development, a B cell can either differentiate into a short-lived plasma cell or into a germinal center B cell after receiving proper activation and co-stimulation. BLIMP … See more Multiple studies have reported high expression of BLIMP-1 in exhausted T cells. T cell exhaustion is usually a result of chronic immune activations, commonly caused by viral infection (e.g. HIV), cancer, or organ transplant. High expression of BLIMP-1 in Tc and … See more SNPs near the PRDM1 gene have been identified in genome-wide association studies (GWAS) to be linked to lupus (SLE) and rheumatoid arthritis (RA). BLIMP-1 represses the expression of the proinflammatory cytokine Interleukin-6 (IL-6), and See more BLIMP-1 promotes naive T-cells to differentiate into T-helper (Th) 2 lineage, while repressing the differentiation into Th1, Th17, and follicular Th. BLIMP-1 is also required for differentiation of cytotoxic T-cell. Specifically, the expression of See more BLIMP-1 has been shown in vitro as a cell lineage determinant in monocytes, inducing their differentiation into DCs and macrophages. … See more Osteoclasts are multinucleated cells that break down and resorb bone tissues. Together with osteoblasts, which form new bones, osteoclast … See more WebPRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations. As a potent repressor of beta-interferon (IFN-β), BLIMP-1 competes for interferon regulatory factors (IRF) binding sites in the IFN-β promoter due to ...
Prdm1 PR domain containing 1, with ZNF domain [ (house mouse)]
WebMay 10, 2024 · PRDM1-involved genes were selected from tissue transcriptome of CRC patients using clinical datasets and their functional evaluation with KEGG pathway … WebNov 5, 2024 · Meanwhile, transcriptome analyses revealed that overexpressed PRDM1 enriched negative regulation of cell proliferation signaling pathway and resulted in a global reduction in IL-2 and inflammatory response signaling pathways. Furthermore, overexpressed PRDM1 in primary T cells upregulated several negative regulators of T cell … dd wrt linksys ea3500
Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of …
WebPRDM1 Protein Overview. PRDM1 is a DNA-binding transcriptional repressor. It exerts its repressive functions through recruitment of histone-modifying enzymes (e.g., HDAC2; 605164) and Groucho corepressors (see 600189) (summary by Smith et al., 2010). WebOct 10, 2013 · PRDM1 is a tumor suppressor gene in an in vitro model of ALCL. (A) PRDM1/BLIMP1 mRNA and protein level after infection with empty vector (pWPI) or vector for BLIMP1 reexpression (pWPI-HA-BLIMP1). ... and MIR17HG is associated with phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway activation. … WebJun 3, 2024 · The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. ... Wnt and EGF-receptor signalling pathways ... dd wrt linksys ea6200