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Tīmeklis2016. gada 1. aug. · Succinate is abundant in synovial fluids from rheumatoid arthritis (RA) patients, and these fluids elicit IL-1β release from macrophages in a GPR91-dependent manner. Together, we reveal a GPR91/succinate-dependent feed-forward loop of macrophage activation and propose GPR91 antagonists as novel therapeutic … TīmeklisSec. 25. Reciprocity requirements. — No foreign chemist shall be admitted to examination, or be given a certificate of registration or be entitled to any of the rights … TīmeklisKeywords: NMR, Metabolomics, Biomarkers, Synovium, Rheumatoid arthritis, Gene expression Background The hallmark of rheumatoid arthritis (RA) is chronic synovitis that affects multiple joints and invades cartilage causing bone erosions and joint destruction [1]. As the synovium is the principal target of inflammation in RA, spy x family release date time