Slc25a11 neuron
WebMay 8, 2024 · These data show that SLC25A11 is a novel paraganglioma susceptibility gene for which loss of function correlates with metastatic presentation. Significance: A gene encoding a mitochondrial... WebSep 23, 2015 · To generate new insights into the biology of Alzheimer’s Disease (AD), we developed methods to combine and reuse a wide variety of existing data sets in new ways. We first identified genes ...
Slc25a11 neuron
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WebAlthough the transport of mGSH is not fully understood, SLC25A10 (dicarboxylate carrier, DIC) and SLC25A11 (2-oxoglutarate carrier, OGC) have been involved in mGSH transport, and therefore we examined their expression and role in HCC. Webdata show that SLC25A11 is a novel paraganglioma susceptibility gene for which loss of function correlates with metastatic presentation. Cancer cells critically depended on the …
WebThe SLC1A3 gene provides instructions for making a protein called excitatory amino acid transporter 1 (EAAT1). EAAT1 transports a molecule called glutamate in the brain. … WebMetabolite analysis of SLC25A11 knockdown cancer cells revealed that the MAS is responsible for ATP production in cancer cells. (a, b) Targeted LC-MS/MS metabolite analysis in UACC62 (a) and A549 ...
WebJan 25, 2024 · We have proposed that the oxoglutarate carrier SLC25A11 is important for ATP production in cancer by NADH transportation from the cytosol to mitochondria as a malate. We have examined not only changes of ATP and NADH but also changes of metabolites after SLC25A11 knock down in cancer cells. Findings WebFeb 1, 2024 · SLC25A11 knockdown suppressed tumor formation in vivo. To test the contribution of SLC25A11 to tumor growth, SLC25A11 was knocked down by shRNA in the A549 and A375 cell lines ( Fig. 5) and the H226 and UACC62 cell lines (Fig. S2), and two knockdown lines were selected from each group for inoculation into mice.
WebDec 1, 2024 · The meaning of mitochondrial movement to a neuron's life. Biochim. Biophys. Acta (2013) G. Lopez-Domenech et al. ... We have proposed that the oxoglutarate carrier SLC25A11 is important for ATP production in cancer by NADH transportation from the cytosol to mitochondria as a malate. We have examined not only changes of ATP and …
WebMay 12, 2024 · : Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell death and mit … six flags screaming eagleWebSLC25A11 is localized in the mitochondrial inner membrane, serving as a mitochondrial GSH transporter to import GSH into mitochondria. Coimmunoprecipitation (Co-IP) analysis revealed that FUNDC2 … six flags schedule new englandWebMar 1, 2024 · Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and … six flags season datesWebThe SLC25 Mitochondrial Carrier Family: Structure and Mechanism Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, … six flags schedule in marylandWebMar 5, 2024 · SLC25A11. solute carrier family 25 member 11. Gene ID: 8402, updated on 5-Mar-2024. Gene type: protein coding. Also known as: OGC; PGL6; SLC20A4. See all … six flags season 2023WebJan 25, 2024 · We have proposed that the oxoglutarate carrier SLC25A11 is important for ATP production in cancer by NADH transportation from the cytosol to mitochondria as a … six flags schedule texasWebApr 18, 2024 · We therefore generated a SLC25A1 neuron transgenic mouse with overexpression specifically in the forebrain neurons. The mice displayed autistic-like … six flags season drink bottle 2021